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Sibutramine tablets (Meridia, Reductil)
Sibutramine (Sibutramine Hydrochloride) (widely known as Meridia) is an anorectic drug that increases the feeling of satiety. It refers to a group of drugs for the treatment of obesity and is used in integrated maintenance therapy of patients with overweight.
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Sibutramine effect
Reduces appetite and food intake (increases satiety), increases thermogenesis (due to indirect activation of β3-adrenergic receptors), has an impact on brown adipose tissue. In the body it forms active metabolites (primary and secondary amines), significantly superior to sibutramine in their ability to inhibit the reuptake of serotonin and norepinephrine.
The decrease in body mass is accompanied by an increase in the concentration of serum HDL and decreasing triglycerides, total cholesterol, LDL and uric acid. During treatment there is a slight rise in blood pressure alone (at 1-3 mm Hg. calendar) and a moderate increased heart rate (3-7 beats/min), but in rare cases, more pronounced changes.
After intake of rapidly absorbed from the gastrointestinal tract is not less than 77%. The “first pass” through the liver biotransformation influenced by the CYP3A4 isoenzyme of cytochrome P450 with the formation of two active metabolites (mono – and didemethylated).
Sibutramine purpose
Anabolic-steroids.24pro.net shop notes that Sibutramine purpose is integrated maintenance therapy of patients with overweight in alimentary obesity with a body mass index of 30 kg/m2 and more or with a body mass index of 27 kg/m2 or more, but in the presence of other risk factors caused by excess weight (diabetes type 2, dislipoproteinemia).
Apply restrictions. Sibutramine side effects
Epilepsy, motor-verbal TIC (involuntary muscle contractions, disturbance of articulation), children and old age (safety and efficacy in children under 18 years of age and in people older than 65 years of age are not determined).
Sibutramine can not be applied to patients who had ever cardiovascular disease.
Sibutramine effects during pregnancy
Application of Sibutramine is restricted during pregnancy and breastfeeding. During pregnancy Sibutramine is not recommended (adequate and well-controlled studies in women have been conducted). Category effects on the fetus by FDA — C. it is unknown whether Sibutramine and its metabolites is in breast milk. In the period of breast-feeding is not recommended.
Overdose
Overdose symptoms: increased severity of side effects, most often — tachycardia, increased blood pressure, headache and dizziness.
Sibutramine: Application and dosage
Inside, 1 time a day (in the morning), the initial dose of 10mg (at bad portability reception is possible 5 mg); in case of insufficient efficacy after 4 weeks dose increased to 15 mg/day.
Precautions. Sibutramine side effects. Sibutramine administration
It is necessary to control blood pressure and pulse rate every 2 weeks during the first 2 months of treatment and then 1 time per month. The emergence during therapy of chest pain, progressive dyspnoea (breathing problems) and edema of the lower extremities may indicate the development of pulmonary hypertension (in this case, be sure to consult a doctor).
It should be borne in mind that sibutramine can reduce saliva and contribute to the development of caries, periodontal diseases, candidiasis and discomfort in the mouth. During treatment it is recommended to limit the consumption of alcohol. It should not be used during the drivers of vehicles and people skills relate to the high concentration of attention.
Special instructions
Application is possible only in cases when all other measures aimed at lowering body weight, ineffective. Treatment must be under the supervision of a doctor with experience correction obesity in the framework of complex therapy (diet, changing your eating habits and lifestyle, increasing physical activity). The period of reception in a dose of 15mg should be limited in time.
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